有机肥生产多以畜禽粪便原料为主，后者是抗生素污染土壤的重要来源之一。通过有机肥抗生素残留检测探究其对生态环境的影响，特别是“有机肥-土壤-农作物”的途径产生影响，对有机肥的安全施用具有重要意义。本数据集采集内蒙古不同地区包括羊粪、牛粪为主的畜禽粪便原料及以其为主要原料的商品有机肥共116份，其中有机肥原料74份，成品42份，进行4种四环类抗生素含量的检测以评估不同畜禽粪便及不同地区存在四环类抗生素风险的可能性，为地区有机肥的安全风险监测和评价提供依据。数据表明，原料土霉素检出率8.62%，四环素检出率10.34%，金霉素检出率10.34%，强力毒素检出率1.72%，商品有机肥金霉素检出率2.58%，强力霉素检出率0.86%，原料抗生素检出率均高于商品有机肥。

Organic fertilizer production is mainly based on livestock and poultry manure raw materials, which is one of the important sources of antibiotic-contaminated soil. It is of great significance to explore the impact of antibiotic residues on the ecological environment of organic fertilizer, especially the impact of the "organic fertilizer-soil-crop" pathway, which is of great significance for the safe application of organic fertilizer. This data set collected a total of 116 samples of sheep manure, cow manure, livestock and poultry manure raw materials and commercial organic fertilizers using livestock and poultry manure as the main raw materials in different regions of Inner Mongolia, including 74 organic fertilizer raw materials and 42 finished products, and the content of 4 tetracyclic antibiotics was detected to evaluate the possibility of tetracyclic antibiotic risks in different livestock and poultry manure and different regions, so as to provide a basis for the safety risk monitoring and evaluation of regional organic fertilizers. The data showed that the detection rate of raw material oxytetracycline was 8.62%, tetracycline 10.34%, chloromycin 10.34%, doxycycline 1.72%, commodity organic fertilizer chloromycin 2.58%, doxycycline 0.86%, and the detection rate of raw antibiotics was higher than that of commercial organic fertilizer.