Animal quarantine is a crucial link in food safety supervision; electronic certification of animal quarantine is highly important toward ensuring food safety. An animal quarantine certificate confirms the safe market conditions for animal husbandry, poultry, and meat products. Such certification efficiently presents information about the state of quarantine; it provides comprehensive tracking of the flow of animals and their products in addition to disease tracing and management responsibility. That certification is vital for food safety and community health. The present study examined ways to enhance anti-tampering and anti-counterfeiting measures with respect to the traceability function of animal quarantine certificates; it aimed to eliminate operational risks and potential food safety hazards during the process of certificate replacement. This paper did so by employing the features of blockchain technology (such as decentralization, anti-tampering, openness, independence, and traceability): it utilized the underlying technical framework of Hyperledger Fabric. An application system for animal quarantine blockchain was designed. A consortium blockchain network was established to link farms, slaughterhouses, distribution stores, and regulators; the chain flow of business processes was followed; quarantine personnel, farms, and other relevant parties jointly recorded invoice and transaction information on the blockchain ledger. Decentralization and inability to tamper with information ensure the safety and transparency of the process of issuing and changing certificates. The department responsible for supervising animal epidemic prevention and quarantine can acquire the supervision node to monitor the entire process of issuing and changing quarantine certificates. This system effectively improves the security and traceability of quarantine applications; it reduces process vulnerabilities, and it improves risk management and control capabilities. Using blockchain technology, this system provides credible, reliable animal quarantine certificates in addition to certificate replacement services. The system integrates technical trust with deposit trust. Thus, blockchain technology is becoming an important technological means to ensure the safety of meat products.